Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p054 | (1) | SRF2016

Inhibition of macrophage colony-stimulating factor-1 (CSF-1) receptor signalling: a novel therapeutic target for tubal ectopic pregnancy

Beaty Robyn , Ahmad S Furquan , Campbell Lisa , Horne Andrew

Introduction: An ectopic pregnancy (EP) is defined as a conceptus implanting outside of the uterine cavity, most commonly in the Fallopian tube. It is a life-threatening gynaecological condition with limited treatment options. Large and unstable EP are managed by surgical excision. Smaller stable EP are medically managed with the chemotherapeutic drug methotrexate. Methotrexate has considerable side effects and a high treatment failure rate (~30%). There is an unmet medical ne...